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Syn-Coll, Pal-KVK, Palmitoyl-Lys-Val-Lys
A synthetic signal peptide that mimics TGF-β activity to stimulate collagen production, reducing wrinkles and improving skin firmness.
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Topical
0.005-0.1% in formulations
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How It Works: Palmitoyl Tripeptide-5 acts as a biomimetic peptide that mimics the activity of thrombospondin-1 to activate latent TGF-β, thereby stimulating collagen synthesis and extracellular matrix production in the skin.
Chen. Wanling W; Xiang. Nanxi N; Huang. Jiahong J; Xu. Huixian H; Wang. Zhenyuan...
A new skin‑care formula packs the peptide palmitoyl‑tripeptide‑5 inside tiny collagen‑lactoferrin particles, boosting its ability to get through the skin; in a 2‑4‑week test users saw more moisture, firmer and more elastic skin, lighter spots and fewer wrinkles.
Shariati Pour. Seyedeh Rojin SR; Oddis. Sara S; Barbalinardo. Marianna M; Ravari...
The study tested a new skin-friendly gel that can hold active peptides. While the gel is safe for cells and has good mechanical properties, it only let one peptide (Trifluoroacetyl tripeptide‑2) pass through the skin. The other peptide we care about, Palmitoyl‑tripeptide‑5, barely crossed the skin barrier.
Avcil. Muhammet M; Akman. Gokhan G; Klokkers. Jens J; Jeong. Dohyeon D; Çel...
A 12‑week study found that hyaluronic‑acid microneedle patches loaded with a mix of skin‑boosting ingredients, including palmitoyl‑tripeptide‑5, were well tolerated and noticeably improved skin appearance: wrinkles dropped about 26%, hydration rose 15%, and the skin’s density and thickness each increased roughly 13‑14%. The results suggest that this multi‑peptide microneedle format can be an effective, non‑invasive way to combat visible signs of aging.