[Tetrapeptide stimulates functional activity of the pancreatic cells in aging].
Khavinson. V Kh VKh; Sevost'ianova. N N NN; Durnova. A O AO; Lin'kova. N S NS; Tarnovskaia. S I SI; Dudkov. A V AV; Kvetnaia. T V TV
Key Findings
- Pancragen raises levels of MMP2, MMP9, serotonin, CD79α, the anti‑apoptotic protein Mcl1, and proliferation markers PCNA and Ki67 in aged pancreatic cell cultures.
- The peptide lowers the pro‑apoptotic protein p53 in the same cells.
- Clinical observations suggest improved pancreatic function in elderly type‑2 diabetes patients who received the peptide.
Practical Outcomes
- The peptide appears to support aging pancreatic cells by promoting growth signals and reducing cell‑death pathways, which could be useful for blood‑sugar control and overall metabolic health. However, without clear dosage, administration route, or safety data, biohackers should treat this as a promising lead rather than a ready‑to‑use supplement.
Summary
A tiny four‑amino‑acid peptide (H‑Lys‑Glu‑Asp‑Trp‑NH2, called pancragen) was shown in lab cells from older people to boost markers of pancreatic cell health and reduce a protein that promotes cell death. The researchers say this could explain why older diabetics who took the peptide felt better, but they don’t give dosing or safety details.
Abstract
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated. It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures. Thus, the capability to activate the expression of signaling molecules--markers of functional activity of pancreatic cells lies behind the clinical effect of studied tetrapeptide observing in elderly patients with type 2 diabetes mellitus.
Study Information
pubmed
2012