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PE-22-28

Spadin analog, TREK-1 inhibitor

A synthetic heptapeptide derived from spadin that selectively inhibits TREK-1 potassium channels, promoting neurogenesis and rapid antidepressant effects.

Quick Stats
Studies 1
Trials 0
Formula C35H55N11O9
Overview Studies 1 Clinical Trials 0
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Utility 2
pubmed Sep 12, 2017

Shortened Spadin Analogs Display Better TREK-1 Inhibition, <i>In Vivo</i> Stability and Antidepressant Activity.

Djillani. Alaeddine A; Pietri. Mariel M; Moreno. S&#xe9;bastien S; Heurteaux. Catherine C; Mazella....

Researchers created a shorter version of the peptide spadin called PE 22-28, which blocks the TREK-1 channel much more strongly (about 500‑times lower IC50) and lasts longer in the body (up to 23 hours vs. 7 hours). In mouse tests, this new peptide reduced depressive‑like behavior, boosted brain cell growth, and increased markers of synapse formation.