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Anticancer peptide PNC-27, Chimeric p53-penetratin peptide
A synthetic 32-amino acid peptide that selectively induces necrosis in cancer cells by binding to HDM-2 on their membranes and forming transmembrane pores.
Mokhtarzadeh. Ahad A; Parhiz. Hamideh H; Hashemi. Maryam M; Abnous. Khalil K; Ramezani. Mohammad M
Scientists attached p53‑derived peptides (PNC‑27/28) to a gene‑carrying carrier and showed it can deliver DNA specifically into cancer cells that display the HDM‑2 protein, while sparing normal cells.
Akinyemi. Joshua O JO; Bolajoko. Izzatullah I; Gbadebo. Babatunde M BM
The study examined if Nigerian mothers who lost a previous child are less likely to use prenatal care, skilled birth assistance, or post‑birth care, and found that once income, education and other factors are considered, the child’s death doesn’t significantly affect service use.
Forastiere. Francesco F; Stafoggia. Massimo M; Picciotto. Sally S; Bellander. Tom T; D'Ippoliti. Dan...
This study looked at people in Rome who died from heart attacks outside the hospital and found that higher levels of tiny particles in the air, larger dust particles, and carbon monoxide on the day they died were linked to a higher chance of death, especially for people over 65.
Wang. Huafeng H; Zhao. Dandan D; Nguyen. Le Xuan LX; Wu. Herman H; Li. Ling L; Dong. Dan D; Troadec....
The study shows that a synthetic peptide called PNC-27 can bind to a special form of the protein HDM2 found only on the surface of acute myeloid leukemia (AML) cells, causing those cancer cells to die while leaving normal blood stem cells unharmed. This effect was demonstrated in mouse models and human AML samples.
Thadi. Anusha A; Morano. William F WF; Khalili. Marian M; Babcock. Blake D BD; Shaikh. Mohammad F MF...
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