Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.
Rogozinskaya. E Ya EY; Lyapina. M G MG
Key Findings
- Selank (Thr‑Lys‑Pro‑Arg‑Pro‑Gly‑Pro) caused the greatest anticoagulant effect among the tested peptides
- All three glyproline peptides shifted thromboelastography parameters (R, K, MA, S, TMA, J) toward hypocoagulation
- The effect was seen across multiple concentrations in the test samples
Practical Outcomes
- The results suggest Selank can thin blood, which might be useful for people looking to reduce clot risk, but the study was done in vitro and provides no dosage guidance for humans. Until clinical trials confirm safety and effective dosing, biohackers should treat this as a preliminary finding and not change any anticoagulant protocols.
Summary
A lab test using a blood‑clotting analyzer showed that Selank and two similar short peptides make blood clot less easily, with Selank having the strongest effect. The study measured several clot‑formation numbers that all shifted toward thinner clotting compared to normal blood.
Abstract
Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.
Study Information
pubmed
2017
2017-11-27T00:00:00.000Z
10.1007/s10517-017-3950-4