Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.
Povarov. I S IS; Kondratenko. R V RV; Derevyagin. V I VI; Myasoedov. N F NF; Skrebitsky. V G VG
Key Findings
- Selank increased amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat CA1 neurons
- Some neurons showed a transient decrease before the increase
- No significant dose‑dependence observed between 1‑8 µM
Practical Outcomes
- The findings are interesting for understanding Selank’s brain activity but don’t translate into actionable dosing or protocols for humans. Biohackers should wait for human‑focused studies before incorporating Selank for anxiety or cognitive benefits.
Summary
In a lab study on rat brain slices, the anxiety‑relief peptide Selank boosted the strength and frequency of natural inhibitory signals in hippocampal neurons, though some cells showed a brief dip before the boost and the effect didn’t change much across the tested concentrations. This is basic neuroscience and doesn’t give clear guidance for human use.
Abstract
Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.
Study Information
pubmed
2017
2017-03-30T00:00:00.000Z
10.1007/s10517-017-3676-3
2
14