State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.
Mukhina. A Yu AY; Medvedeva. O A OA; Svishcheva. M V MV; Shevchenko. A V AV; Efremova. N N NN; Bobyntsev. I I II; Kalutskii. P V PV; Andreeva. L A LA; Myasoedov. N F NF
Key Findings
- Chronic restraint stress decreased obligate (good) gut microbes and increased opportunistic (bad) microbes in rats.
- Selank injected at 80, 250, or 750 µg/kg 15 minutes before stress restored a healthier microbiota balance.
- The microbiota restoration is thought to involve both central (brain‑related) and peripheral (immune‑related) mechanisms.
Practical Outcomes
- Selank may help protect gut health during stress, suggesting a gut‑brain benefit, but the study was done in rats using injections, so there’s no clear human dosing or protocol yet. More human research is needed before it can be used as a practical stress‑gut supplement.
Summary
In rats, stress messed up the gut bacteria, lowering the good ones and letting bad ones grow, but giving Selank before the stress helped keep the good bacteria and stop the bad ones from taking over.
Abstract
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
Study Information
pubmed
2019
2019-06-24T00:00:00.000Z
10.1007/s10517-019-04496-y
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