[A comparative analysis of distribution of glyprolines administered by various routes].
Ashmarin. I P IP; Baglikova. K E KE; Edeeva. S E SE; Zolotarev. Iu A IuA; Kozik. V S VS; Dadaian. A K AK; Dorokhova. E M EM; Alfeeva. L Iu LIu; Andreeva. L A LA; Kopylova. G N GN; Pavlov. T S TS; Vas'kovskiĭ. B V BV; Meshavkin. V K VK; Sokolov. O Iu OIu; Kost. N V NV; Zozulia. A A AA; Samonina. G E GE; Miasoedov. N F NF
Key Findings
- Intranasal delivery gave the highest selank concentrations in the brain
- All administration routes resulted in strong accumulation of selank in gastric tissue
- Intranasal route is optimal for targeting central nervous system effects
Practical Outcomes
- If you want selank to act on the brain, use an intranasal spray rather than oral or injection routes. Expect significant gut exposure regardless, so monitor any gastrointestinal effects. This route can help you design a more efficient self‑experiment protocol for cognitive or neuro‑protective goals.
Summary
In rats, the peptide selank reaches the brain best when given through the nose, while it piles up in the stomach no matter how you take it. This means a nasal spray is the most efficient way to get selank’s effects in the central nervous system, and you’ll also get strong exposure to the gut.
Abstract
The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes in concentrations of the peptides in the rat organs after their intraperitoneal, intranasal, intragastric, and intravenous administration are given. The intranasal administration of both peptides was shown to be optimal for the delivery of glyproline molecules in the CNS. A high affinity of the studied glyprolines for gastric tissues was found for all the ways of their administration. We suggest that a high efficiency of action of glyprolines on homeostasis of the gastric mucous tunic was partially provided by accumulation of these peptides (to high concentrations) in gastric tissues.
Study Information
pubmed
2008
10.1134/s1068162008040043