[Peptidergic modulation of the hippocampus synaptic activity].
Skrebitskiĭ. V G VG; Kondratenko. R V RV; Povarov. I S IS; Dereviagin. V I VI
Key Findings
- Selank (2 µM) raised the frequency of spike‑dependent spontaneous inhibitory postsynaptic currents in hippocampal CA1 pyramidal neurons
- Spike‑independent inhibitory events were unchanged, suggesting a specific effect on activity‑driven signaling
- The results support the idea that Selank activates inhibitory interneurons, similar to the nootropic Noopept
Practical Outcomes
- Selank appears to modulate inhibitory signaling in the hippocampus, which could contribute to its reported calming and cognitive benefits. Because the data come from isolated brain tissue, there is no actionable dosage or protocol for human use yet. Enthusiasts should view this as mechanistic insight and await human studies before adjusting their regimens.
Summary
In a lab study on mouse brain slices, Selank (2 µM) increased the frequency of spike‑dependent inhibitory signals onto hippocampal CA1 pyramidal cells, indicating it likely activates inhibitory interneurons, which may underlie its anxiolytic and cognitive‑enhancing claims; however, the experiment was done in vitro and does not provide direct dosing guidance for humans.
Abstract
Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged. It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells. Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion, at least for Noonent.
Study Information
pubmed
2011