[Effect of selank on the main carboxypeptidases in the rat nervous tissue].
Solov'ev. V B VB; Gengin. M T MT; Sollertinskaia. T N TN; Latynova. I V IV; Zhivaeva. L V LV
Key Findings
- Selank alters the activity of carboxypeptidase H and a related enzyme in rat nervous tissue.
- The enzyme activity changes persist for up to 24 hours after one dose.
- These enzyme changes could be a way selank regulates neuropeptide levels.
Practical Outcomes
- For self‑experimenters, the data hint that selank’s effects may last at least a day, so daily dosing could be sufficient to maintain its influence on neuropeptide systems. However, the study is mechanistic and does not provide direct evidence of performance or health benefits, so any protocol should be approached as exploratory and combined with personal monitoring.
Summary
A single dose of selank changes the activity of two brain enzymes that control the breakdown of certain neuropeptides, and these changes last for about a day. This suggests selank might influence how long neuropeptides stay active in the brain.
Abstract
Effect of single selank administration on activity of carboxypeptidase H and of phenylmethylsulfonylfluoride-inhibited carboxypeptidase - enzymes detaching arginine and lysine from C-terminus of molecules-precursors of biologically active peptides was studied. The preparation has been shown to cause long, preserved for 24 h changes of activities of these carboxypeptidases. It is suggested that the change in activity of the studied enzymes can be one of mechanisms of regulation of level of neuropeptides at action of selank.
Study Information
pubmed
2012