Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.
Mukhina. A Yu AY; Mishina. E S ES; Bobyntsev. I I II; Medvedeva. O A OA; Svishcheva. M V MV; Kalutskii. P V PV; Andreeva. L A LA; Myasoedov. N F NF
Key Findings
- Chronic restraint stress caused colon wall atrophy, inflammation, and increased corticosterone in rats.
- Selank administered 15 minutes before stress lowered corticosterone levels.
- Selank reduced the gut damage and accelerated physiological adaptation to stress.
- Three doses (80, 250, 750 µg/kg) were tested, showing dose‑related effects.
Practical Outcomes
- Selank shows promise as an anti‑stress agent that may protect gut health, but the evidence is limited to animal models with injectable doses. Biohackers should treat this as preliminary data and wait for human safety and dosing studies before trying it. It does not yet provide a concrete, safe protocol for personal use.
Summary
In stressed rats, the gut lining gets damaged and stress hormones go up. Giving the peptide Selank before stress lowered the stress hormone corticosterone, reduced gut damage, and helped the animals adapt faster. The study was done in rats with injections, not humans.
Abstract
We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 μg/kg 15 min before stress exposure. In rats subjected to stress, signs of atrophy, inflammatory reaction, and changes in the number and functional activity of mast cells were observed against the background of increased corticosterone level. Selank administration led to a decrease in corticosterone levels, reduced pathomorphological manifestations of stress exposure, and accelerated adaptation. These effects were presumably realized due to multifunctional biological effects of Selank.
Study Information
pubmed
2020
2020-07-10T00:00:00.000Z
10.1007/s10517-020-04868-9
4
15