[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].
Medvedev. V E VE; Tereshchenko. O N ON; Israelian. A Iu AIu; Chobanu. I K IK; Kost. N V NV; Sokolov. O Iu OIu; Miasoedov. N F NF
Key Findings
- Selank produced a pronounced anxiolytic (anti‑anxiety) effect in patients with phobic‑anxiety and somatoform disorders.
- A mild nootropic (cognitive‑enhancing) effect was observed alongside the anxiety reduction.
- The anxiolytic benefit persisted for roughly one week after the final administration, and patients reported improved quality of life.
Practical Outcomes
- For self‑directed health optimizers, selank appears to be a potentially effective, longer‑lasting alternative to benzodiazepines for anxiety, with added mild cognitive benefits and good tolerability. While exact dosing and administration routes aren’t detailed here, the findings support experimenting with selank in a controlled, low‑dose regimen to assess personal response, especially for those seeking non‑sedating anxiety relief.
Summary
A study with 60 people who have anxiety disorders found that the peptide selank reduced anxiety and gave a mild boost to thinking abilities. The calming effect lasted about a week after the last dose, and patients reported a better overall quality of life. Selank was also well‑tolerated compared with the traditional drug phenazepam.
Abstract
Objective. To study the efficacy and tolerability of the new anxyolytic peptide selank in comparison with phenazepam. Material and methods. A comparative study of the anxiolytic effect and tolerability of selank and phenazepam was carried out in 60 patients with phobic-anxiety- and somatoform disorders (F40.2-9, F41.1-9, F45.0-1 by ICD-10) were examined. Results Pronounced anxiolytic and mild nootropic effects of selank were demonstrated. The anxiolytic effect lasted for a week after last receiving the peptide. Selank had a positive impact on the quality of life of the patients. Conclusion. The data obtained in the study extend therapeutic possibilities in the treatment of anxiety disorders.
Study Information
pubmed
2014