[The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity].
Seredenin. S B SB; Semenova. T P TP; Kozlovskaia. M M MM; Medvinskaia. N I NI; Nezovibat'ko. V N VN
Key Findings
- Both taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) lowered stress‑related behavior in rats with chronically low serotonin.
- The peptides helped normalize brain serotonin levels after chronic depletion.
- TP-7 showed stronger anxiolytic and psychostimulant effects than the shorter taftcine.
Practical Outcomes
- These results suggest that short peptide fragments can influence anxiety and serotonin balance, but the data are limited to an animal model with a specific serotonin deficiency. For biohackers, the study provides a hint that TP-7 might be a more potent candidate than taftcine, yet no human dosing, safety, or efficacy information is available, so it’s not ready for direct self‑experimentation.
Summary
In rats that had their serotonin system weakened, two short peptides called taftcine and a longer version TP-7 reduced stress reactions, made the animals explore more calmly, and brought brain serotonin levels back toward normal. TP-7 worked a bit better than the shorter taftcine.
Abstract
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine. Intracutaneous administration of both peptides (300 micrograms/kg) was found to result in weakening perception of stress situations; an increase in stability of investigation behavior and normalization of serotonin level in the brain of rats with chronic deprivation of serotoninergic system activity. Anxiolytic and psychostimulant activities of TP-7 are more pronounced than those of tafcine.
Study Information
pubmed
1995