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Selank

Selanc, TP-7

Quick Stats
Studies 114
Trials 11
Overview Studies Clinical Trials
Score 3
2003 pubmed

[Highly stable regulatory oligopeptides: experience and applications].

Ashmarin. I P IP; Bakaeva. Z V ZV; Vas'kovskiĭ. B V BV; Zheliaznik. N Ia NIa; Zhuĭkova. S E SE; Zolotarev. Iu A IuA; Kamenskiĭ. A A AA; Levitskaia. N G NG; Liapina. L A LA; Miasoedov. N F NF

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Key Findings

  • Glyprolines are highly stable regulatory peptides that survive the digestive tract and enter the bloodstream.
  • In rat studies, glyprolines reduced gastric ulcer formation, inhibited blood clot formation, and improved diabetic markers.
  • The peptides can be combined with connective‑tissue food proteins for oral delivery.

Practical Outcomes

  • For now, the data are limited to animal models, so there’s no ready‑to‑use protocol for humans. However, the oral bioavailability and multi‑target effects make glyprolines worth watching for future supplement or therapeutic development, especially for gut health, clot prevention, and metabolic support.

Summary

Researchers found that a new group of tiny proteins called glyprolines are very stable, can get into the bloodstream when taken by mouth, and showed promising anti‑ulcer, blood‑clot‑preventing, and blood‑sugar‑lowering effects in rats. They think these peptides could become drugs for stomach ulcers, clot disorders, and diabetes, but they’re still in early animal testing.

Abstract

The most stable regulatory peptides (RP) including the new family of RP (glyprolines) and derivatives of hybrid peptide MEHFPGP are characterized. High ability of glyprolines to penetrate into the blood-stream through the gastrointestinal tract is demonstrated. Antiulcer, antithrombotic and antidiabetic activities of glyprolines were discovered in experiments on white rats. The activity of oligopeptides PGP, PG and GP is compared. Mechanisms of glycoprolines activities and feasibility of their administration with connective tissue food proteins are discussed. Thus, glyprolines are perspective drugs for treatment of gastric ulcer, correction of hemostasis and thrombosis suppression prepared for preclinical trial.

Study Information

Provider

pubmed

Year

2003