Measure:
Change in blood cortisol levels
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in blood cortisol levels in micrograms per deciliter (ug/dl) will be measured
Measure:
Change in blood Adrenocorticotropic hormone (ACTH) levels
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in blood ACTH levels in picograms per milliliter (pg/ml) will be measured
Measure:
Change in heart rate
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in rate (in beats per minute)
Measure:
Change in State Anxiety levels as assessed by the State-Trait Anxiety Inventory (STAI)
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in composite STAI score. Scale consists of 20 items assessing state anxiety levels; each item is on 4 point Likert scale ranging from 1 (not at all) to 4 (almost always). Items are summed to obtain a composite score which can range from 20 to 80 (higher scores indicate more anxiety).
Measure:
Change in Mood state as assessed by the The Profile of Mood States (POMS)
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in total tension-anxiety sub-scale score for POMS. This sub-scale of the POMS consists of 9 items, each on a 4-point Likert scale ranging from 1 (not at all) to 4 (extremely) which are summed to create a total score of 9 to 36 (higher scores indicate more tension/anxiety).
Measure:
Change in Positive affect levels as assessed by The Positive and Negative Affect Schedule (PANAS)
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in total positive affect score. This PANAS consists of 20 items assessing positive affect (10 items) and negative affect (10 items). Each item is on a 5-point Likert scale ranging from 1 (very slightly or not at all) to 5 (extremely). 10 positive affect items are summed to create a total positive affect score while the 10 negative affect items are summed to create a total negative affect score; higher total scores indicate more positive affect or more negative (i.e., worse) affect.
Measure:
Change in Negative affect levels as assessed by The Positive and Negative Affect Schedule (PANAS)
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Peak change in total negative affect score. This PANAS consists of 20 items assessing positive affect (10 items) and negative affect (10 items). Each item is on a 5-point Likert scale ranging from 1 (very slightly or not at all) to 5 (extremely). 10 positive affect items are summed to create a total positive affect score while the 10 negative affect items are summed to create a total negative affect score; higher total scores indicate more positive affect or more negative (i.e., worse) affect.
Measure:
Subjective rating of "Drug Effect" as assessed via the Drug Effect Questionnaire
TimeFrame:
Prior to drug exposure and for 4 hours post-exposure.
Description:
Visual Analog Scale rating of subjective drug effect. Score ranges from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.