Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of "Social" Stress.
Samotrueva. M A MA; Yasenyavskaya. A L AL; Murtalieva. V Kh VK; Bashkina. O A OA; Myasoedov. N F NF; Andreeva. L A LA; Karaulov. A V AV
Key Findings
- Social stress caused multidirectional immune disturbances in the animals
- Semax restored both cellular and humoral immune responses
- Semax improved neutrophil phagocytic activity
Practical Outcomes
- Semax may have potential as an immune‑support tool to offset stress‑related immune decline, but the evidence is limited to animal models. Until human safety and dosing are clarified, it isn’t ready for a concrete DIY protocol, though it signals a possible avenue for future biohacking research.
Summary
In a mouse study, stress from social fighting messed up the animals' immune system, but giving them the peptide Semax helped bring immune functions back toward normal, including better white‑blood‑cell activity.
Abstract
We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of "social" stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs. It was found that changes in the immune response caused by "social" stress are multidirectional, which confirms the theory of stress-induced "immune imbalance". Semax acted as effective immune corrector restoring cellular and humoral immunogenesis reactions and phagocytic activity of neutrophils. This attested to the presence of immunomodulating properties in Semax and necessitates further studies in this field.
Study Information
pubmed
2019
2019-04-26T00:00:00.000Z
10.1007/s10517-019-04434-y
6
4