Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH<sub>(4-7)</sub>-PGP (Semax).
Svishcheva. M V MV; Mishina. Ye S YS; Medvedeva. O A OA; Bobyntsev. I I II; Mukhina. A Y AY; Kalutskii. P V PV; Andreeva. L A LA; Myasoedov. N F NF
Key Findings
- Restraint stress caused colon wall atrophy, inflammation, and higher blood corticosterone in rats
- Pre‑treatment with Semax reduced corticosterone levels and lessened colon tissue damage
- Semax appeared to promote gut adaptation to stress, likely via its multifunctional neuropeptide actions
Practical Outcomes
- Semax may have gut‑protective effects during acute stress, but there’s no human data or clear dosing guidance yet. For now, it’s an interesting lead that requires more research before being incorporated into personal health protocols.
Summary
In a rat study, giving the peptide Semax before a stressful situation lowered stress hormones and reduced damage and inflammation in the colon, suggesting the drug helps the gut cope with acute stress. However, the work was done in animals, used high doses, and didn’t test humans, so the findings are not ready for direct use by biohackers.
Abstract
We studied the effect of intraperitoneal administration ACTH<sub>(4-7)</sub>-PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. In rats exposed to restraint stress, signs of atrophy and inflammatory reaction in the colon wall, changes in functional activity and number of mast cells, and increased serum level of corticosterone were observed. Administration of the peptide led to a decrease in corticosterone concentration, alleviated stress-induced pathomorphological changes, and promoted adaptation of the intestinal wall to stress. The positive effects of ACTH<sub>(4-7)</sub>-PGP can be determined by multifunctional nature of the physiological and pharmacological effects of the neuropeptide.
Study Information
pubmed
2021
2021-01-18T00:00:00.000Z
10.1007/s10517-021-05072-z
4
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