Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax.
Gavrilova. S A SA; Markov. M A MA; Berdalin. A B AB; Kurenkova. A D AD; Koshelev. V B VB
Key Findings
- Semax reduced the increase of sympathetic nerve fibers in the heart’s ventricular septum after injury
- Semax did not alter the density of β1 and β2 adrenoceptors in the heart
- The effect was observed 28 days after the ischemia/reperfusion event in rats
Practical Outcomes
- For now, there’s no direct protocol to use Semax for heart health in humans. The finding hints at a possible protective role after heart damage, but more research is needed before biohackers can consider it a safe or effective supplement for cardiovascular benefits.
Summary
In a rat study, the peptide Semax was given after a simulated heart attack and was found to slow down the growth of nerve fibers that control heart activity, without changing the number of certain heart receptors. This suggests Semax might influence heart healing, but the research is early and done in animals only.
Abstract
The effect of peptide Semax on remodeling of cardiac sympathetic innervation was examined in rats with experimental myocardial infarction. In 28 days after ischemia/reperfusion injury, Semax diminished the growth of sympathetic innervation of ventricular septum, although it produced no effect on the density of β<sub>1</sub> and β<sub>2</sub> adrenoceptors.
Study Information
pubmed
2017
2017-09-25T00:00:00.000Z
10.1007/s10517-017-3862-3
2
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