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Semax

ACTH(4-10) analogue, Heptapeptide SEMAX

Quick Stats
Studies 172
Trials 37
Overview Studies Clinical Trials
Score 2
2017 pubmed

Influence of ACTG<sub>4-7</sub>-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress.

Ivanov. A V AV; Bobyntsev. I I II; Shepeleva. O M OM; Kryukov. A A AA; Andreeva. L A LA; Myasoedov. N F NF

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Key Findings

  • Semax reduced stress‑related liver enzyme (ALT) elevation and helped normalize protein synthesis in the liver
  • Higher doses showed a stronger anti‑cell‑death (anticytolytic) effect, with more multinucleated hepatocytes
  • Liver repair signs increased, indicating enhanced constitutive protein synthesis

Practical Outcomes

  • Semax may have liver‑protective properties during chronic stress, but the data come from high‑dose injections in rats. Until human studies confirm safety and effective oral or injectable dosing, it isn’t ready for a DIY protocol; consider it an interesting lead rather than a proven supplement.

Summary

In rats under chronic emotional and painful stress, giving the peptide semax (ACTG4-7-PGP) by injection helped protect liver cells: it lowered damage markers, improved protein‑making activity, and the effect got stronger with higher doses.

Abstract

We studied the effect of intraperitoneal administration of peptide ACTG<sub>4-7</sub>-PGP to male Wistar rats in doses of 5, 50, 150, and 450 &#x3bc;g/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein.

Study Information

Provider

pubmed

Year

2017

Date

2017-06-03T00:00:00.000Z

DOI

10.1007/s10517-017-3748-4