Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex.
Romanova. G A GA; Silachev. D N DN; Shakova. F M FM; Kvashennikova. Yu N YN; Viktorov. I V IV; Shram. S I SI; Myasoedov. N F NF
Key Findings
- Intranasal Semax reduced the size of cortical infarcts in a photo‑induced ischemia model
- Semax improved retention in a conditioned passive avoidance test
- The treatment was given for six consecutive days post‑injury
Practical Outcomes
- For biohackers, this suggests Semax might have neuroprotective and memory‑supporting effects after brain injury, but the evidence is from animal experiments only. It isn’t a ready‑to‑use protocol for healthy people, though it adds to the idea that nasal Semax could be explored for brain health support under medical supervision.
Summary
In a lab study, giving the peptide Semax through the nose for six days helped protect brain tissue and memory after a small, experimentally induced stroke in the front part of the brain. The treated animals had smaller damaged areas and remembered a learned avoidance task better than untreated ones.
Abstract
Semax had a pronounced neuroprotective and antiamnesic effect during focal photoinduced ischemia of the prefrontal cortex. Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.
Study Information
pubmed
2006
2006-12-01T00:00:00.000Z
10.1007/s10517-006-0445-0
17
16