Score
1
2008
pubmed
1 citations
Audiogenic epilepsy in young mice of different strains after neonatal semax treatment.
Boyarshinova. O S OS; Perepelkina. O V OV; Markina. N V NV; Poletaeva. I I II
Key Findings
- Neonatal semax injections (days 2‑7) reduced audiogenic seizure susceptibility in DBA/2J mice
- No reduction was seen in the other four inbred mouse strains tested
- The effect was measured by lower seizure scores and fewer deaths at one month of age
Practical Outcomes
- The result is specific to a mouse strain and to treatment given right after birth, so it doesn’t provide a usable protocol for humans or adult biohackers. It suggests that semax’s anti‑seizure effects may depend on genetics and developmental timing, indicating more research is needed before any real‑world application.
Summary
Giving newborn mice a peptide called semax for a few days lowered the chance they would have seizures triggered by loud sounds, but this only happened in one specific mouse strain (DBA/2J) and not in four other strains.
Abstract
Neonatal (from day 2 to day 7 of life) injection of neuropeptide semax to mice of 5 inbred strains significantly reduced predisposition to audiogenic epilepsy in only one-month-old DBA/2J mice, which manifested in changes in the mean audiogenic sensitivity score and percentage of animals dead as a result of acoustic stimulation.
Study Information
Provider
pubmed
Year
2008
Date
2008-11-26T00:00:00.000Z
DOI
10.1007/s10517-008-0212-5
Citations
1
References
5