Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
Umarova. B A BA; Kopylova. G N GN; Smirnova. E A EA; Guseva. A A AA; Zhuikova. S E SE
Key Findings
- Stress boosts mast cell secretory activity in rat gut and fat tissue
- Semax (0.05 mg/kg) given an hour before stress blocks this increase
- In vitro, Semax prevents mast cell activation by typical stimulants
Practical Outcomes
- Semax may act as a mast‑cell stabilizer, potentially reducing stress‑related gut inflammation or ulcer risk. However, the evidence is limited to animal studies with injection dosing, so more research is needed before recommending it for human use or oral protocols.
Summary
In rats, stress makes certain immune cells in the gut and fat release more chemicals, which can lead to ulcers. Giving the peptide Semax (and a similar peptide) before the stress stops this extra activity, but only when the animals are stressed. The same effect was seen in lab dishes, suggesting Semax can calm these cells and might help protect the gut under stress.
Abstract
Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.
Study Information
pubmed
2003
10.1023/b:bebm.0000010942.14275.50