Natural and hybrid ("chimeric") stable regulatory glyproline peptides.
Ashmarin. I P IP; Samonina. G E GE; Lyapina. L A LA; Kamenskii. A A AA; Levitskaya. N G NG; Grivennikov. I A IA; Dolotov. O V OV; Andreeva. L A LA; Myasoedov. N F NF
Key Findings
- Glyproline peptides have stability comparable to conventional drugs
- They can cross gastrointestinal barriers, opening the possibility of oral administration
- Hybrid “chimeric” peptides that combine natural regulatory peptides may enhance stability and broaden therapeutic potential
Practical Outcomes
- For DIY biohackers this means oral semax could be feasible, and pairing semax with other peptides might improve its action, but specific dosing and safety data are still lacking and should be tested carefully.
Summary
The abstract says that glyproline peptides like semax are surprisingly stable in the body and can survive the gut, so they might be taken as pills, and that mixing them with other natural peptides could boost their overall effect.
Abstract
The present concept of relative instability of regulatory peptides (RPs) in organisms must be amended. The recently characterized family of glyprolines and some other prolyl-glycyl-proline (PGP)-containing oligopeptides show the stability quite comparable with those of major pharmacological preparations. The ability of glyprolines to pass gastro-enteric tract barriers opens ways to per-oral administration of this new group of drugs such as semax, selank and their fragments. The most interesting approach is the creation of hybrid ("chimeric") peptide drugs combining the unmodified representatives of various natural RPs that distinctly manifest their inherent physiological activities and cooperate with each other in stabilization of whole peptide in vivo. As the result, the activity of such peptides as semax and selank may have value in a vide variety of pathological processes.
Study Information
pubmed
2005
10.1016/j.pathophys.2004.10.001