Audiogenic epilepsy in mice with different genotypes after neonatal treatments enhancing neurogenesis in dentate gyrus.
Timoshenko. T V TV; Perepelkina. O V OV; Markina. N V NV; Revischin. A V AV; Pavlova. G V GV; Poletaeva. I I II; Sukhih. G T GT
Key Findings
- Semax given to neonatal rats (50 mg/kg) increased neurogenesis in the dentate gyrus.
- Both semax and L‑NAME altered the pattern of audiogenic seizures at one month of age.
- The impact on seizure severity differed by rat genotype and was not directly linked to the amount of neurogenesis.
Practical Outcomes
- For biohackers, this study shows semax can influence brain development and seizure susceptibility in early life animal models, but it offers no clear, safe protocol for adult humans seeking longevity or performance benefits. The high neonatal dose and species‑specific effects limit direct applicability.
Summary
In newborn rats, giving the peptide semax (or a nitric‑oxide blocker) for a few days boosted brain cell growth in a part of the hippocampus and later changed how the animals responded to sound‑triggered seizures, but the severity of seizures varied depending on the rat strain. The changes weren’t simply tied to how much new brain cells formed, hinting at other underlying mechanisms.
Abstract
Pups of Wistar and KM rats (with predisposition to audiogenic epilepsy) were daily injected with neuropeptide semax (50 mg/kg) or NO-synthase inhibitor L-NAME (50 mg/kg) on days 7-11 of life. Alterations of audiogenic seizures pattern were revealed in rats of both strains at the age of 1 month, while changes in seizure severity were genotype-dependent. Both agents enhance neurogenesis in the dentate gyrus of the hippocampus and the delayed effect in the form of altered seizure pattern seems to be determined by this factor. Genotype-dependent alterations of seizure severity after administration of semax and L-NAME were differently directed. These effects are suggested to be underlined by physiological and biochemical mechanisms not related to the intensity of postnatal neurogenesis.
Study Information
pubmed
2009
2009-08-20T00:00:00.000Z
10.1007/s10517-009-0558-3
3
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