Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment.
Boyarshinova. O S OS; Shilova. O B OB; Markina. N V NV; Gichenok. I V IV; Perepelkina. O V OV; Poletaeva. I I II
Key Findings
- Neonatal solvent (water/saline) lowered pain thresholds in adult male DBA/2, 101/HY, and RSB mice but not females or other strains
- Neonatal Semax raised pain thresholds in adult male DBA/2 and 101/HY mice compared to solvent‑treated controls
- Neonatal buspiron reduced pain thresholds in adult male RLB mice
Practical Outcomes
- The results show that early‑life exposure to Semax can affect pain sensitivity later, but only in specific mouse genotypes and males. This finding doesn’t translate into a clear protocol for adult humans and offers little actionable guidance for biohackers seeking longevity or performance benefits.
Summary
In a mouse study, giving newborns a drug called Semax changed how sensitive they were to pain as adults, but only in certain male mouse strains. Giving just water or salt solution to newborns also altered pain sensitivity in some strains, while another drug, buspiron, lowered pain thresholds in a different strain. These effects were specific to the mouse genetics and sex.
Abstract
We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes. Neonatal administration of the solvent (nociceptive stimulation) decreased pain thresholds in DBA/2, 101/HY, and RSB males, but not in female mice and animals of other strains. Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent. Injection of buspiron in the neonatal period decreased pain thresholds in RLB males.
Study Information
pubmed
2004
10.1023/b:bebm.0000042703.99534.40