Effect of acute progestational hypoxia on the content of biogenic amines in the brain of albino rat pups: Peptide correction.
Maslova. M V MV; Graf. A V AV; Sokolova. N A NA; Goncharenko. E N EN; Shestakova. S V SV; Kudryashova. N Yu NY; Andreeva. L A LA
Key Findings
- brains.",
- , "A single intranasal dose of semax given to pregnant rats prevented the hypoxia‑induced changes in the offspring
Practical Outcomes
- While the results hint that semax might have neuroprotective effects against low‑oxygen stress, the study is limited to rats and prenatal exposure. There’s no direct protocol for adult biohackers, and more human research is needed before considering any practical use.
Summary
A study in rats showed that low oxygen levels during pregnancy can mess up brain chemicals important for stress and mood in the pups, and that giving the mother a nasal spray of the peptide semax (and another peptide) prevented these changes. This was an animal experiment, not a human trial, and it focused on prenatal brain development rather than adult health.
Abstract
We studied the effect of exposure to acute hypobaric hypoxia in the progestational period on the content of biogenic amines in the brainstem and cerebral cortex in rat pups of different age. The possibility of correcting hypoxia-induced changes with regulatory peptides was evaluated. We found that early antenatal hypoxia disturbs maturation of catecholaminergic systems in the brain. It should be emphasized that the differences from the control varied depending on the age of rat pups. Single intranasal administration of Semax heptapeptides and beta-casomorphine-7 to pregnant females prevented changes in the content of biogenic amines in CNS of the offspring during postnatal ontogeny.
Study Information
pubmed
2003
10.1023/a:1026346302541