[Effects of neonatal fluvoxamine administration to white rats and their correction by semax treatment].
Volodina. M A MA; Merchieva. S A SA; Sebentsova. E A EA; Glazova. N Iu NIu; Manchenko. D M DM; Andreeva. L A LA; Levickaia. N G NG; Kamenskiĭ. A A AA; Miasoedov. N F NF
Key Findings
- Neonatal fluvoxamine slowed growth and reduced body weight in rats
- Fluvoxamine increased anxiety and impaired learning in the animals
- Semax treatment after fluvoxamine largely restored normal growth, anxiety levels, and learning ability
Practical Outcomes
- Semax showed promise in reversing developmental side‑effects of an SSRI in rats, suggesting potential neuroprotective properties. However, because the work is in newborn rats, it doesn’t provide a ready‑to‑use protocol for humans and should be viewed as early‑stage evidence only.
Summary
In baby rats, giving the antidepressant fluvoxamine caused slower growth, lower weight, more anxiety, and poorer learning. When the peptide semax was given later, many of these problems were fixed. The study shows semax can reverse some early‑life drug effects in rats, but it’s an animal study and not directly usable for humans yet.
Abstract
The aim of this work was to study the delayed effects of chronic neonatal administration of the selective serotonin reuptake inhibitor fluvoxamine (FA) to white rat pups and to estimate the possibility to correct these effects by treatment with semax. Fluvoxamine was injected intraperitoneally at a dose of 10 mg/kg from postnatal days 1 to 14, and semax was injected intranasally at a dose of 0.05 mg/kg from postnatal days 15 to 28. It was shown that neonatal FA administration produced a significant delay in animal somatic growth. A loss in body weight was detected both during FA administration and 4-6 weeks after the last injection. Furthermore, FA administration increased the anxiety level and disturbed the learning ability of animals. The negative consequences of neonatal FA administration were largely compensated by Semax.
Study Information
pubmed
2014