[THE EFFECT OF ACTH-(4-7)-PGP PEPTIDE ON LIPID PEROXIDATION IN LIVER AND ACTIVITY OF SERUM TRANSAMINASES IN RATS UNDER ACUTE AND CHRONIC IMMOBILIZATION STRESS CONDITIONS].
Bobyntsev. I I; Kryukov. A A AA; Shepeleva. M M; Ivanov. A V AV
Key Findings
- Semax showed antioxidant effects in liver cells across all tested doses in stressed rats
- High dose (450 µg/kg) markedly increased serum ALT and AST, indicating possible liver strain under chronic stress
- Mid dose (150 µg/kg) caused pro‑oxidant effects during acute stress, and enzyme changes varied with dose
Practical Outcomes
- For DIY health enthusiasts, the data suggest that very high semax doses could stress the liver, especially during prolonged stress, while lower doses might offer antioxidant benefits in animal models. However, because the study is in rats and uses injection, the findings aren’t directly transferable to oral or nasal use in humans, so caution and further research are needed before applying these doses.
Summary
In rats, giving the peptide semax (ACTH‑(4‑7)‑PGP) by injection changed how the liver handled oxidative stress and liver enzymes. Low to medium doses acted like an antioxidant, while a very high dose (450 µg/kg) raised liver enzyme levels, especially under long‑term stress. A mid‑range dose (150 µg/kg) actually increased oxidative damage during short‑term stress.
Abstract
The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied. It was found that the peptide administration in the entire dose range studied produced antioxidant effect in hepatocytes and significantly increased the activity of serum ALT and AST at a dose of 450 μg/kg under chronic stress conditions. On the contrary, prooxidant effects were observed at a drug dose of 150 mg/kg under acute stress conditions, and the direction of changes in the ALT and AST values activity depended on the semax dose. The ALT activity was decreased at doses of 5 and 50 μg/kg, but increased at a dose of 450 μg/kg. The AST activity was already reliably increased at a dose of 5 μg/kg.
Study Information
pubmed
2015