Score
2
2009
pubmed
[Effect of semax on heart rate variability in various daytime periods].
Arushanian. E B EB; Popov. A V AV
Key Findings
- No HRV change with semax in the morning
- Evening semax reduced stress‑induced sympathetic effects on the heart
- Suggests semax has a time‑dependent, chronotropic activity
Practical Outcomes
- If you’re using semax, the study hints that taking it later in the day might help blunt stress‑related heart effects, but it’s an animal study and human results aren’t proven yet. Consider timing as a variable to test, but don’t rely on it for definitive benefits.
Summary
In rats, the nootropic peptide semax didn’t change heart‑rate variability (HRV) when given in the morning, but in the evening it helped keep the heart’s nervous‑system balance steadier during stress, hinting it might act differently depending on the time of day.
Abstract
Peptide drug semax with nootropic properties did not change the heart rate variability in rats in the morning, but produced a significant optimizing action and attenuated the stress-induced sympathetic influences on the heart in the evening. It is suggested that semax has a chronotropic activity, which may participate in realization of the specific drug action.
Study Information
Provider
pubmed
Year
2009