Score
2
2008
pubmed
[Chronotropic activity of semax].
Arushanian. E B EB; Popov. A V AV
Key Findings
- Semax normalized the circadian locomotor rhythm in rats
- It increased the amplitude and shifted the acrophase of activity cycles
- It reduced the overall chronobiological index, indicating a more synchronized rhythm
Practical Outcomes
- The study suggests Semax might influence circadian timing, which could be interesting for sleep or performance hacks, but it’s only an animal experiment. No human dosing or safety data are provided, so it’s not ready for direct use in protocols.
Summary
In rats, giving the nootropic peptide Semax over a long period helped their daily activity cycles become more regular and stronger, shifting the peak activity time and smoothing out the rhythm pattern.
Abstract
The chronic administration of nootropic drug Semax, a peptide analog of ACTH (4-10), normalized the circadian locomotor rhythm in rats (with an increase in its amplitude, a shift in the acrophase, and a change of the spectral characteristics) and reduced the integral chronobiological index. It is suggested that the rhythm-synchronizing chronotropic activity may be a part of the specific effect of this cognitive enhancer.
Study Information
Provider
pubmed
Year
2008