[New regulatory peptides in rat stomach secretion (amylin, PGP, semax)].
Maev. I V IV; Dicheva. D T DT
Key Findings
- Semax reduced both baseline and vagus‑stimulated hydrochloric acid secretion in rats.
- Semax lowered basal and stimulated pepsinogen release from the stomach.
- Semax caused a short‑term increase in bicarbonate secretion about 35 minutes after dosing.
Practical Outcomes
- Semax shows potential as a gastro‑protective agent in animal models, but there’s no human data or oral dosing guidance yet. Biohackers should view this as an early‑stage finding and wait for clinical studies before considering it for ulcer prevention or gut health.
Summary
In rats, the peptide semax lowered the amount of stomach acid and the enzyme pepsinogen that can damage the gut, and it briefly boosted the stomach's protective bicarbonate. This suggests semax might help protect against ulcers, but the study was done in animals and used injection, so it isn’t a ready‑to‑use protocol for people.
Abstract
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate. The intraperitoneal introduction of these peptides in the doses that proved to have an apparent anti-ulcer effect caused a decrease of both basal production of hydrochloric acid in the stomach and production caused by the irritation of the vagus nerve. Semax and amylin also decreased basal and stimulated secretion of pepsinogen. Amylin and PGP did not have any effect on basal bicarbonate secretion of the stomach, and semax caused its short-time increase 35 minutes after the introduction. We made a conclusion that the decrease of aggressive factors in gastric juices can be a mechanism of the anti-ulcer action of all three peptides under study.
Study Information
pubmed
2003