[The nootropic correction of disorders in learning and memory processes induced by extreme exposures].
Iasnetsov. V V VV; Krylova. I N IN; Popov. V M VM
Key Findings
- Extreme exposures caused retrograde amnesia in rats
- Oxiracetam, aniracetam, nooglutil, meclofenoxate, pyracetam and GABA fully prevented the memory loss
- Semax was only effective under one or two of the extreme conditions
Practical Outcomes
- Semax may not be a reliable shield against severe memory‑impairing stressors, so biohackers should not count on it for broad neuro‑protection. Other racetam‑type compounds showed more consistent protection in this animal model, but human relevance is still uncertain.
Summary
In rats, strong stressors like intense electromagnetic fields, motion sickness, and electric shocks wiped out memory, but many racetam‑type nootropics stopped this loss. Semax only helped in a couple of the stress tests, not across the board, so its protective effect seems limited.
Abstract
Experiments on rats demonstrated that the low-intensity electromagnetic field (12.6 cm, 2375 MHz, power density 1 mW/cm2), motion sickness, and electroconvulsive shock provoked the retrograde amnesia in the passive avoidance test. The oxyracetam (100 mg/kg, i.p.), aniracetam (50 mg/kg, i.p.), nooglutil (50 mg/kg, i.p.), meclofenoxate (50 mg/kg, i.p.), pyracetam (200 mg/kg, i.p.), and GABA (200 mg/kg, i.p) prevented the memory-impairing effect of all these extreme factors. On the contrary, the N-acetylglycinamide, semax, and other nootropic drugs were effective only under one or two extreme conditions.
Study Information
pubmed
1996