Score
2
1986
pubmed
[Hormonal activity of the ACTH(4-10) analog--a prolonged-action stimulant of learning].
Ponomareva-Stepnaia. M A MA; Porunkevich. E A EA; Skuin'sh. A A AA; Nezavibat'ko. V N VN; Ashmarin. I P IP
Key Findings
- Semax (ACTH4‑10 analog) was evaluated for hormonal activity
- It did not show steroidogenic (steroid‑hormone‑producing) effects
- It did not exhibit melanocyte‑stimulating (melanin‑producing) activity
Practical Outcomes
- For DIY users, semax appears not to interfere with cortisol or melanin pathways, reducing concerns about hormonal side effects. This safety insight is useful, but the abstract provides no information on cognitive or performance benefits, so dosing or efficacy decisions still need other evidence.
Summary
The study checked if semax, a short ACTH fragment used by some biohackers, triggers hormone production. It found that semax does not boost steroid hormones or melanin, meaning it likely won’t cause cortisol spikes or skin‑pigment changes.
Abstract
Possible hormonal activity of ACTH4-7, a long-acting ACTH4-10 analog (ProGly Pro) was studied. Unlike ACTH5-10 the peptide did not reveal steroidogenic and melanocyte-stimulating activity.
Study Information
Provider
pubmed
Year
1986