[The comparison of neuroprotective action of antibodies to glutamate and drug preparation semax in the focal ischemic damage of the brain prefrontal cortex of rats].
Romanova. G A GA; Shakova. F M FM; Davydova. T V TV
Key Findings
- Intranasal semax (250 µg/kg daily for six days) reduced the volume of cortical damage after photothrombotic stroke in rats.
- Semax‑treated rats performed better on a passive‑avoidance memory test, indicating protection against memory loss.
- The neuroprotective effect of semax was comparable to that of an anti‑glutamate antibody administered shortly after injury.
Practical Outcomes
- The study suggests that intranasal semax might have brain‑protective properties, but it is an early animal experiment. No human dosing or safety data are available, so biohackers should treat this as a preliminary hint rather than a ready‑to‑use protocol.
Summary
In a rat study, giving the peptide semax through the nose after a stroke‑like injury helped shrink the damaged brain area and kept the animals from forgetting a learned task. The effect was similar to that of an anti‑glutamate antibody.
Abstract
It was stated, that with bilateral photochemically induced thrombosis of the prefrontal cortex peptide semax and the AB-Glu by intranasal injection provoke pronounced neuroprotective and antiamnestic action. Intranasal injection semax (250 mkg/kg/daily during six postoperative days) and AB-Glu (250 mkg/kg in 1 hour after phototrombosis) demonstrate diminishing of cortex damage volume and relieve preservation and reproduction rat passive avoidance reflex, acquired before bilateral photochemically induced thrombosis of prefrontal cortex.
Study Information
pubmed
2012