[Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease].
Polunin. G S GS; Nurieva. S M SM; Baiandin. D L DL; Sheremet. N L NL; Andreeva. L A LA
Key Findings
- Semax administered nasally (drops or electrophoresis) accelerated visual recovery in optic nerve disease.
- Patients showed measurable improvements in visual acuity, visual field extent, optic nerve conductivity, and color vision.
- The peptide appeared to protect nerve tissue during the acute phase of injury when combined with standard neurotrophic and anti‑inflammatory therapy.
Practical Outcomes
- For biohackers, this suggests semax may have neuroprotective properties that could be useful beyond eye health, but the evidence is limited to a specific eye condition. The study does not provide clear dosing guidelines for general use, so anyone considering semax should treat it as experimental and look for more data on safety and broader neurological effects.
Summary
In a clinical study, people with optic nerve problems were given the peptide semax either as nasal drops or via a special nasal electric treatment. Adding semax to their standard care helped them recover vision faster, improving sharpness, visual field size, nerve signal strength, and color perception.
Abstract
Semax is a synthetic analog of adrenocorticotropic hormone 4-10 with a pronounced nootropic effect. It was used in the treatment of vascular, toxic allergic, and inflammatory diseases of the optic nerve and partial atrophy of the optic nerve in parallel with basic neurotrophic and antiinflammatory therapy. For evaluating the drug efficiency, the patients were divided into 3 groups, administered the drug via different routes. In group 1 semax was administered intransally as nasal drops, in group 2 by endonasal electrophoresis, and group 3 was control. Addition of semax to therapeutic complex in patients with diseases of the optic nerve had a favorable impact on the intensity and rate of recovery and improved the visual functions. Semax effectively protected nervous tissue from aftereffects of injury, particularly during the acute stage of optic nerve disease: it stimulated positive changes in the clinical picture, which were evaluated by improvement of visual acuity, extension of the total visual field, increase in the electric sensitivity and conductivity of the optic nerve, and improvement of color vision.
Study Information
pubmed
2000