[An experimental substantiation for using the "Semax" neuroprotector in the treatment of optic-nerve diseases].
Sheremet. N L NL; Polunin. G S GS; Ovchinnikov. A N AN; Kamenskiĭ. A A AA; Levitskaia. N G NG; Andreeva. L A LA; Alfeeva. L Iu LIu; Nagaev. I Iu IIu
Key Findings
- Intranasally administered, tritium‑labeled Semax quickly penetrates the brain and ocular tissues in rats.
- Semax remains chemically stable and does not break down when subjected to an electric field.
- The peptide moves from the positive to the negative electrode, indicating a specific electrophoretic mobility direction.
Practical Outcomes
- For biohackers, the main takeaway is that intranasal delivery of Semax appears feasible for targeting the central nervous system and eyes, at least in animal models. While the study doesn’t provide human dosing guidelines, it supports using nasal sprays as a potential route for neuroprotective experiments. Users should treat this as preliminary evidence and await human safety and efficacy data before routine use.
Summary
The study shows that the peptide Semax can be given through the nose and still reach the brain and eyes in rats, and it stays stable when exposed to an electric field. This suggests that intranasal Semax could be a practical way to deliver the drug for neuroprotective purposes, but the results are still limited to animal experiments.
Abstract
In order to substantiate the feasibility of using the "Semax" neuroprotector in the treatment of optic-nerve diseases its pharmacokinetics in the intranasal administration was studied in experiments with rats; besides, the physical-and-chemical properties of "Semax" were investigated to define the preparation's stability and mobility in the electric field. A series of experiments, involving a tritium-marked "Semax", showed that the peptide actively penetrates into the brain and eyes of experimental animals after its intranasal administration. It was established, within a study aimed at determining the electrophoretic activity and stability of "Semax" in the electric field, that the preparation does not disintegrate in the electric field, it posses the electrophoretic mobility and moves, in the electric field, from plus to minus; therefore, the "Semax" solution must be fed from anode while making the electrophoresis procedure.
Study Information
pubmed
2004