[Study of neuroprotective, antihypoxic and antiamnesic effects of new mixture of tripeptides].
Iasnetsov. V V VV; Chertorizhskiĭ. E A EA; Belyĭ. P A PA; Bespalova. Zh D ZhD; Ovchinnikov. M V MV; Vereshchagina. A O AO; Ivanov. Iu V IuV; Iasnetsov. Vik V VV; Kirsanova. S K SK; Motin. V G VG
Key Findings
- NMT reduced neurological deficits after brain ischemia more effectively than semax (1.1‑fold improvement).
- NMT showed stronger antihypoxic effects than semax, especially at higher doses (up to 1.9‑fold better).
- NMT provided superior anti‑amnesic benefits compared to semax in several animal memory‑loss models (1.4‑4‑fold improvements).
Practical Outcomes
- For biohackers, the study suggests that a tripeptide blend similar to semax might offer enhanced neuroprotection and cognitive benefits, but the data are limited to animal models and high doses. Until human trials are available, the findings are more useful for guiding future research or for cautious experimentation with semax‑like compounds rather than immediate protocol changes.
Summary
In rats and mice, a new mix of three short peptides (called NMT) protected the brain from damage caused by lack of oxygen, reduced memory loss, and improved brain signaling better than the known peptide drug semax. The effects were seen at doses ranging from 10 to 150 mg per kilogram of body weight.
Abstract
A new mixture of tripeptides (NMT: H-Lys-Asp-Glu-OH, H-Asp-Glu-Pro-OH, H-Asp-Glu-Arg-OH) in doses of 150 and 300 mg/kg per day produces clearly pronounced neuroprotective effect in rats with brain ischemia and decreases neurologic deficiency 1.1 times more effectively than reference drug semax. NMT (10, 50 and 150 mg/kg) had marked antihypoxic effect on mice in hermetic and altitude chamber. NMT in doses of 10 and 50 mg/kg was more effective than semax in hermetic chamber (1.3 and 1.5 times, respectively) and in a dose of 150 mg/kg in altitude chamber (1.9 times). NMT (50 and 150 mg/kg) had also marked antiamnesic effect on model amnesia caused by scopolamine in rats and was more effective (1.5 and 1.4 times, respectively) than semax in equal doses. NMT (50 and 150 mg/kg) also had marked antiamnesic effect on model amnesia caused by maximal electroshock and complex extreme factors in mice and in both doses was 4 times more effective than semax on the first model and in a dose of 150 mg/kg was 2.9 times more effective on the second model. NMT (50 mg/kg) increased the amplitude of transcallosal evoked potential in rat brain by 69% and was more effective than semax in equal dose. Thus, NMT is a promising neurotropic drug with neuroprotective, antihypoxic and antiamnesic activity.
Study Information
pubmed
2015