Effect of Semax on homeostasis of gastric mucosa in albino rats.
Zhuikova. S E SE; Smirnova. E A EA; Bakaeva. Z V ZV; Samonina. G E GE; Ashmarin. I P IP
Key Findings
- Semax given intraperitoneally (50 µg/kg) reduced gastric damage caused by ethanol and stress in rats.
- A 5‑day post‑injury Semax regimen prevented acetic‑acid‑induced ulcers and promoted ulcer healing.
- The anti‑ulcer effect of Semax was comparable to the tripeptide Pro‑Gly‑Pro at a dose of 1 mg/kg.
Practical Outcomes
- The study suggests Semax may have gut‑protective properties, but it was done only in rats using injections, not oral dosing. For biohackers, the result is interesting but not ready for direct use; more research (especially human trials and practical delivery methods) is needed before it can be incorporated into self‑care protocols.
Summary
In rats, a single injection of the peptide Semax (50 µg per kg) given an hour before a stomach‑damaging challenge protected the stomach lining, and a five‑day course after an acid injury helped prevent ulcers and speed up healing. Its effect was similar to another small peptide known to protect the gut.
Abstract
The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.
Study Information
pubmed
2000