[A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study)].
Asmarin. I P IP; Nezavibat'ko. V N VN; Miasoedov. N F NF; Kamenskiĭ. A A AA; Grivennikov. I A IA; Ponomareva-Stepnaia. M A MA; Andreeva. L A LA; Kaplan. A Ia AIa; Koshelev. V B VB; Riasina. T V TV
Key Findings
- Intranasal Semax (0.015‑0.050 mg/kg) improves operative memory and attention in animals and healthy humans.
- The cognitive and circulatory benefits persist for 20‑24 hours after a single dose.
- Semax increases resistance to hypoxia and enhances brain circulation without reported adverse effects.
Practical Outcomes
- For biohackers, a single low‑dose intranasal spray of Semax could be used as a daily or pre‑challenge cognitive enhancer, especially in demanding or low‑oxygen environments. The long‑lasting effect means dosing once per day may be sufficient, and the safety record suggests it can be tried with minimal risk.
Summary
Semax is a nasal spray peptide that, at very low doses, can boost memory, focus, and brain blood flow for up to a day, and it also helps the brain cope with low‑oxygen situations. It has been used safely in both animals and healthy people, with no reported side effects.
Abstract
Semax is one of the rare analogues of regulatory peptides which underwent all stages from fundamental investigations to practical usage. It has been demonstrated that this peptide is capable to stimulate operative memory and attention, to increase resistance to hypoxia and to improve brain circulation in experimental animals and human beings over prolonged period (20-24 h after intranasal administration in doses 0.015-0.050 mg/kg). Semax significantly improves memory and attention in healthy men under extreme conditions of activities. Moreover at present semax is successfully used in treatment of patients with different diseases of CNS. In the majority of cases the peptide exhibited positive effects and in no case it produced negative side actions or complications connected with its administration. There is good reason to believe that medical potentialities of semax have not been exhausted and in future new possibilities of its usage will be revealed.
Study Information
pubmed
1997