[Comparison of the effects of thyroliberin and ACTH4-7 PGP on the learning of rats during the solving of spatial orientation tasks].
Chepurnova. N E NE; Guseva. A A AA; Efimova. E V EV; Mart'ianov. A A AA; Chepurnov. S A SA
Key Findings
- Both TRH (100 µg/kg) and ACTH4-7 Pro‑Gly‑Pro (15‑25 µg/kg) sped up spatial learning on radial and T‑mazes.
- Treated rats chose the correct arm more often after short (5‑10 min) delays, indicating better short‑term memory.
- Working and reference memory in a reinforced place task improved, and the two compounds did not interfere with each other.
Practical Outcomes
- These results suggest that semax‑like peptides might have cognitive‑enhancing effects, but the evidence is limited to rodents and specific doses. For biohackers, the study provides a hint that low‑dose ACTH4-7 derivatives could be explored for learning benefits, yet human safety, effective dosing, and real‑world impact remain unproven, so any experimentation should be approached with caution and further research.
Summary
In rats, giving tiny amounts of the brain chemicals TRH and a short piece of the ACTH hormone (the part used to make the nootropic peptide semax) made them learn maze tasks faster and remember them better, without the two drugs messing with each other's effects.
Abstract
The influence of TRH (100 micrograms/kg) and ACTH4-7 Pro-Gly-Pro (15 micrograms/kg and 25 micrograms/kg) involved an acceleration of the spatial learning on the 12-arm radial maze and on T-maze in rats; an increase in the number of correct choice after short (5-10 min) retention interval; and affected the working and reference spatial memory in the test of reinforced place performance. The effects of the TRH and ACTH4-7 Pro-Gly-Pro did not interfere with one another.
Study Information
pubmed
1989