Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency.
Sopwith. A M AM; Penny. E S ES; Grossman. A A; Savage. M O MO; Besser. G M GM; Rees. L H LH
Key Findings
- In six patients with hypothalamic hGRF deficiency, blood hGRF rose after a mixed breakfast.
- Baseline hGRF was ~13.6 pg/ml and peaked at ~29 pg/ml 2 hours after eating.
- The rise implies a significant extrahypothalamic (peripheral) source of hGRF.
Practical Outcomes
- For biohackers, the data hint that sermorelin could have effects beyond stimulating growth hormone, possibly influencing metabolism directly in tissues. However, the paper doesn’t provide dosing tips or clear performance benefits, so it’s more background info than a protocol change.
Summary
The study measured a natural growth‑hormone‑releasing factor (hGRF) in people whose brain’s hormone‑release center was damaged and found that after a normal breakfast their blood levels still rose, showing the body can make this peptide outside the brain. This suggests hGRF (and its drug version, sermorelin) might act in peripheral tissues, not just the brain.
Abstract
Using a highly specific radioimmunoassay we have measured the concentrations of human growth hormone releasing factor (ir-hGRF) in the peripheral circulation of six individuals with acquired hypothalamic hGRF deficiency. Despite their hypothalamic dysfunction venous plasma ir-hGRF increased normally in every patient after the stimulus of a mixed breakfast, from an average concentration basally of 13.6 +/- 6.0 pg/ml to a maximum of 29.0 +/- 8.4 pg/ml (mean +/- SEM) at 120 min. The findings indicate that circulating hGRF is at least in large part extrahypothalamic in origin, which in turn implies a physiological role for hGRF in the periphery.
Study Information
pubmed
1986
1986-04-01T00:00:00.000Z
10.1111/j.1365-2265.1986.tb01643.x
16
31