Menu
Submit Data
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Back to Studies

Sermorelin

GHRH (1-29), GRF 1-29 NH2, Sermorelin acetate

Quick Stats
Studies 223
Trials 41
Overview Studies Clinical Trials
Score 2
1986 pubmed

Growth hormone responses to growth hormone-releasing factor (1-29) in euthyroid, hypothyroid and hyperthyroid rats.

Dieguez. C C; Jordan. V V; Harris. P P; Foord. S S; Rodriguez-Arnao. M D MD; Gomez-Pan. A A; Hall. R R; Scanlon. M F MF

View on DOI View Original Source

Key Findings

  • Hypothyroid rats showed a 5‑ to 6‑fold lower GH surge after sermorelin compared with normal rats.
  • Hyperthyroid rats had a modest reduction in GH levels only 30 minutes after a higher sermorelin dose.
  • The data imply that thyroid status alters pituitary somatotroph sensitivity to GH‑releasing factor.

Practical Outcomes

  • If you plan to use sermorelin for growth‑hormone boosting, make sure your thyroid function is normal first; hypothyroidism may blunt the effect. Hyperthyroidism might slightly reduce the peak response, especially at higher doses. Monitoring thyroid hormones could help optimize sermorelin dosing and outcomes.

Summary

In rats, low thyroid (hypothyroid) makes the pituitary less responsive to sermorelin, a growth‑hormone‑releasing peptide, while high thyroid (hyperthyroid) causes a smaller, later drop in response. This suggests thyroid health can influence how well sermorelin works.

Abstract

In order to investigate whether the impaired GH secretion associated with hypothyroidism and hyperthyroidism is due to a hypothalamic or a pituitary disorder, we have studied plasma GH responses to GH-releasing factor (1-29) (GRF) in euthyroid, hypothyroid and hyperthyroid rats. Hypothyroid rats showed a significant (P less than 0.001) reduction in GH responses to GRF (5 micrograms/kg) at 5 min (350 +/- 35 vs 1950 +/- 260 micrograms/l), 10 min (366 +/- 66 vs 2320 +/- 270 micrograms/l) and 15 min after GRF injection (395 +/- 72 vs 1420 +/- 183 micrograms/l; mean +/- S.E.M.) compared with euthyroid rats. Hyperthyroid rats showed a significant (P less than 0.05) decrease in GH responses to 5 micrograms GRF/kg after 30 min (200 +/- 14 vs 325 +/- 35 micrograms/l) but not at other time-points, or after the administration of 1 microgram GRF/kg. These data indicate that in hypothyroidism and perhaps hyperthyroidism there is an alteration in the responsiveness of the somatotroph to GRF administration.

Study Information

Provider

pubmed

Year

1986

DOI

10.1677/joe.0.1090053