[Sequential infusion of GHRH 1-29NH2, LHRH and TRH for evaluating the hypophyseal reserve. Comparison with Politest].
Grossi. A A; Barbetti. F F; Bulletta. C C; Ciampalini. P P; Jaffrain-Rea. M L ML; Tamburrano. G G
Key Findings
- Adding GHRH to the standard LHRH+TRH+insulin test (Politest B) raised TSH levels more than the classic test (Politest A).
- Growth hormone responses were similar between the two test versions and matched the response to GHRH alone in most cases.
- FSH, LH, and prolactin responses did not differ significantly between the test protocols.
Practical Outcomes
- For biohackers or self‑experimenters, this research offers little direct guidance on using sermorelin for performance, body composition, or longevity. It mainly informs clinicians about diagnostic testing, not about dosing or efficacy for health optimization.
Summary
The study compares different hormone‑challenge tests to see how well they assess pituitary function in patients with pituitary lesions and healthy volunteers. It shows that adding GHRH (the same peptide in sermorelin) to a standard test changes thyroid‑stimulating hormone levels but doesn’t improve growth hormone responses compared to the classic test.
Abstract
Fourteen patients with pituitary lesions and 6 normal subjects underwent the following tests: a) LHRH (100 mcg) + TRH (200 mcg) + Human Insulin (0.1 UI/kg) i.v. (Politest "A"); b) LHRH (100 mcg) + TRH (200 mcg) + GHRH 1-29NH2 (100 mcg) i.v. (Politest "B"); c) GHRH 1-29NH2 (100 mcg) i.v. (GHRH-TEST). FSH, LH and PRL, as assayed in patients and controls in response to Politest "A" and "B", revealed no significant differences between the tests. Plasma TSH values were significantly higher after Politest "B" in both patients and normals. The GH response after Politest "A" and "B" was similar in magnitude and concordant in 88.8% of cases.
Study Information
pubmed
1989