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4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide
A small molecule ERR agonist that mimics exercise by activating estrogen-related receptors to enhance metabolism, muscle endurance, and treat metabolic disorders.
| Route | |
|---|---|
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Intraperitoneal (IP, animal studies)
50 mg/kg twice daily
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How It Works: SLU-PP-332 acts as a pan-agonist for estrogen-related receptors (ERRα, ERRβ, ERRγ), triggering metabolic pathways similar to those activated during aerobic exercise, promoting energy expenditure and tissue repair.
Billon. Cyrielle C; Schoepke. Emmalie E; Avdagic. Amer A; Chatterjee. Arindam A;...
Scientists created a lab-made molecule called SLU-PP-332 that turns on the same cellular pathways that get activated during aerobic exercise. In obese mice, the drug boosted calorie burning, helped burn more fat, cut down on weight gain, and made the animals more sensitive to insulin, basically mimicking many of the health benefits of regular exercise.
Xu. Weiyi W; Billon. Cyrielle C; Li. Hui H; Wilderman. Andrea A; Qi. Lei L; Grav...
Scientists made a new compound called SLU‑PP‑332 that turns on a group of proteins (ERR receptors) that help the heart use fat for energy. In mice with a type of heart failure, the drug improved heart pumping, reduced scar tissue, and helped the animals live longer, mainly by boosting mitochondrial function and fatty‑acid metabolism. However, this work is still in animals, so there’s no human dosing or safety data yet.
Wang. Xiaoxin X XX; Myakala. Komuraiah K; Libby. Andrew E AE; Krawczyk. Ewa E; P...
In old mice, a drug called SLU‑PP‑332 that activates estrogen‑related receptors (ERRs) acted like lifelong calorie restriction: it lowered kidney leak (albuminuria), protected kidney cells, improved mitochondrial health, and cut inflammation. The benefits seemed to work through the STING‑STAT3 signaling pathway. A separate STING inhibitor also helped, but unexpectedly boosted the same mitochondrial and ERR markers.