Menu
Submit Data
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Back to Profile

SLU-PP-332

4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide

A small molecule ERR agonist that mimics exercise by activating estrogen-related receptors to enhance metabolism, muscle endurance, and treat metabolic disorders.

Quick Stats
Studies 4
Trials 0
Formula C18H14N2O2
Overview Studies 4 Clinical Trials 0
Clear All
Utility 3
pubmed Mar 29, 2023

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.

Billon. Cyrielle C; Sitaula. Sadichha S; Banerjee. Subhashis S; Welch. Ryan R; Elgendy. Bahaa B; Heg...

Scientists created a new compound called SLU-PP-332 that activates a protein family (ERRs) important for muscle performance. In mouse studies, the drug boosted mitochondrial activity, shifted muscle fibers toward a more endurance‑friendly type, and let the animals run longer. The effect depended mainly on the ERRα subtype, suggesting it could act like a “exercise pill.”

Utility 3
pubmed Sep 17, 2023

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.

Wang. Xiaoxin X XX; Myakala. Komuraiah K; Libby. Andrew E AE; Krawczyk. Ewa E; Panov. Julia J; Jones...

In old mice, a drug called SLU‑PP‑332 that activates estrogen‑related receptors (ERRs) acted like lifelong calorie restriction: it lowered kidney leak (albuminuria), protected kidney cells, improved mitochondrial health, and cut inflammation. The benefits seemed to work through the STING‑STAT3 signaling pathway. A separate STING inhibitor also helped, but unexpectedly boosted the same mitochondrial and ERR markers.

Utility 2
pubmed Nov 14, 2023

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

Xu. Weiyi W; Billon. Cyrielle C; Li. Hui H; Wilderman. Andrea A; Qi. Lei L; Graves. Andrea A; Rideb....

Scientists made a new compound called SLU‑PP‑332 that turns on a group of proteins (ERR receptors) that help the heart use fat for energy. In mice with a type of heart failure, the drug improved heart pumping, reduced scar tissue, and helped the animals live longer, mainly by boosting mitochondrial function and fatty‑acid metabolism. However, this work is still in animals, so there’s no human dosing or safety data yet.

Utility 2
pubmed Jan 17, 2024

A Synthetic ERR Agonist Alleviates Metabolic Syndrome.

Billon. Cyrielle C; Schoepke. Emmalie E; Avdagic. Amer A; Chatterjee. Arindam A; Butler. Andrew A AA...

Scientists created a lab-made molecule called SLU-PP-332 that turns on the same cellular pathways that get activated during aerobic exercise. In obese mice, the drug boosted calorie burning, helped burn more fat, cut down on weight gain, and made the animals more sensitive to insulin, basically mimicking many of the health benefits of regular exercise.