TB-500

Thymosin Beta-4, TB4, Tβ4

A synthetic peptide that promotes tissue repair, reduces inflammation, and enhances healing by regulating actin polymerization and cell migration.

Molecular Profile

Formula C₂₁₂H₃₅₀N₅₆O₇₈S

Mol. Weight 4963 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Subcutaneous (SC) 2-5 mg twice weekly	2-5 mg twice weekly	High (95%)	SUB
Intramuscular (IM) 2-5 mg twice weekly	2-5 mg twice weekly	High (95%)	INT
Oral 10-20 mg/kg (animal studies)	10-20 mg/kg (animal studies)	Low (10%)	ORA

How It Works

How It Works: TB-500 facilitates tissue repair and regeneration primarily by modulating actin dynamics, which influences cell structure, movement, and various healing processes.

Actin Sequestration: Binds to G-actin monomers, preventing polymerization and promoting cell motility and migration essential for wound healing.
Angiogenesis Promotion: Stimulates the formation of new blood vessels to improve blood flow to damaged tissues.
Anti-Inflammatory Effects: Reduces inflammation by modulating cytokine production and immune responses.
Stem Cell Differentiation: Enhances mobilization and differentiation of stem/progenitor cells for tissue regeneration.

Pairs Well With

Latest Clinical Trials

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Terminated PHASE2 NCT00311766

A Phase 2 Study on Effect of Thymosin Beta 4 on Wound Healing in Patients With Epidermolysis Bullosa

RegeneRx Biopharmaceuticals, Inc.

INTERVENTIONAL

Updated Dec 15, 2025

Completed PHASE3 NCT02974907

Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2

ReGenTree, LLC

INTERVENTIONAL

Updated Dec 15, 2025

Withdrawn PHASE2 NCT01311518

A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction

RegeneRx Biopharmaceuticals, Inc.

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 2

pubmed Jul 18, 2025

Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens' performance, gene expression, intestinal histomorphometry, blood indices, and litter.

Ismael. Elshaimaa E; Kamel. Shaimaa S; Elleithy. Ebtihal M M EMM; Bekeer. Manal...

A study on chickens showed that different forms of butyrate (a gut‑friendly fatty acid) can boost growth, improve gut lining, and lower some blood markers. Tributyrin (TB‑300) helped the birds gain more weight and use feed more efficiently, while coated sodium butyrate (SB‑500) cleaned up litter bacteria. All the butyrate types raised blood proteins and digestive enzymes, and changed gut‑related gene activity.

Utility 3

pubmed Feb 7, 2024

Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro.

Rahaman. Khandoker Asiqur KA; Muresan. Anca Raluca AR; Min. Hophil H; Son. Jungh...

The study shows that the peptide TB-500 itself isn’t toxic and doesn’t speed up wound healing, but one of its breakdown products, called Ac‑LKKTE, does help wounds close faster. The researchers also mapped how TB‑500 is broken down in the body, finding that another fragment, Ac‑LK, appears quickly and another, Ac‑LKK, sticks around for days.

Utility 3

pubmed Sep 5, 2017

Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5.

Judák. Péter P; Van Eenoo. Peter P; Deventer. Koen K

Peptides like TB-500 can stick to the walls of test tubes and bottles, which means you might lose some of the dose when you handle them. The study shows that not all fancy low‑bind containers work the same for every peptide, so you need to pick the right kind based on the peptide’s chemistry.

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