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Tesamorelin

Egrifta, TH9507

Quick Stats
Studies 64
Trials 24
Completed OBSERVATIONAL NCT03826160

Growth Hormone Dynamics and Cardiac Steatosis in HIV

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Cardiac steatosis is increased among individuals with HIV, and may predispose to cardiac mechanical dysfunction and subsequent heart failure. The pathogenesis and treatment of cardiac steatosis is not well understood. The investigators have previously shown that perturbed growth hormone (GH) secretion in HIV contributes to ectopic fat accumulation in the viscera and the liver. Moreover, the investigators have found that augmentation of endogenous GH secretion with the FDA-approved medication tesamorelin reduces visceral and hepatic fat. In this longitudinal observational study, the investigators will examine patients with HIV and abdominal fat accumulation who either plan or do not plan to initiate tesamorelin prescribed clinically. The investigators hypothesize that blunted GH secretion in HIV is associated with cardiac steatosis. The investigators also hypothesize that use of tesamorelin for 6 months is associated with a reduction in intramyocardial fat and preserved cardiac function.

Primary Outcomes

Measure: Intramyocardial lipid content
TimeFrame: 6 months
Description: Measure of fat content within cardiac muscle as assessed by cardiac magnetic resonance spectroscopy (MRS)

Trial Information

NCT ID

NCT03826160

Status

Completed

Study Type

OBSERVATIONAL

Sponsor

Massachusetts General Hospital

Last Updated

December 15, 2025