Menu
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Tesamorelin

Egrifta, TH9507

Quick Stats
Studies 64
Trials 24
Recruiting PHASE2 INTERVENTIONAL NCT03150511

Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial recovery of motor and sensory function following surgical repair of injured peripheral nerves. Patients with upper extremity nerve injuries will be randomly assigned to receive either tesamorelin treatment or no treatment. Assessments for nerve regeneration, muscle function, and sensation will be conducted every three months for a total of 12 months. Outcomes in patients receiving tesamorelin will be compared to those in the untreated group to determine the effectiveness of tesamorelin as a therapeutic intervention for nerve injuries.

Detailed Description

This is a randomized, double-blinded, clinical trial assessing the efficacy of tesamorelin as a therapy to improve functional recovery following peripheral nerve injury. Tesamorelin is a drug that stimulates increased production of growth hormone, and growth hormone has been shown to improve nerve regeneration and functional recovery in animal studies. A total of 36 participants with repaired ulnar nerve lacerations will be enrolled, of which 18 will be randomly assigned to receive the study drug and 18 will receive no treatment. To minimize bias, outcome assessors and the biostatistician analyzing the data will be blinded to the treatment assignments. Following enrollment, each participant will have 12 monthly follow-up visits during which participants will undergo testing to assess recovery. Outcome assessments will include clinical exams, electrodiagnostic studies and questionnaires. The total duration of the study is expected to be 4 years.

Interventions

Name: Tesamorelin 2 Milligrams (MG)
Type: DRUG
Description: Daily self-administered study drug

Primary Outcomes

Measure: 3-point chuck pinch test
TimeFrame: 12 months
Description: Pinch strength measure as measured by a pinch gauge.

Trial Information

NCT ID

NCT03150511

Status

Recruiting

Study Type

INTERVENTIONAL

Phases

PHASE2

Sponsor

Johns Hopkins University

Last Updated

December 15, 2025