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Thymalin

Thymulin, Thymic Factor, Serum Thymic Factor, Facteur Thymique Serique

A synthetic thymic nonapeptide that modulates immune function by promoting T-cell differentiation and enhancing overall immunity.

Molecular Profile
Formula C33H54N12O15
Mol. Weight 858.9 g/mol
Sequence Gly-Glu-Pro-Pro...
Route
Subcutaneous (SC)
3-10 mg
SUB
Intramuscular (IM)
5-10 mg
INT
Oral
10-20 mg
ORA

How It Works

How It Works: Thymalin functions as an immunomodulatory peptide that regulates immune responses by influencing thymic activity and cellular processes, primarily through epigenetic mechanisms and gene expression modulation.

  • Promotes differentiation and proliferation of T-lymphocytes and stem cells
  • Regulates gene expression for cytokines, heat-shock proteins, and gerontogenes
  • Enhances NK cell activity and balances immune responses to prevent overactivation
  • Reduces apoptosis in immune cells and supports thymic function restoration.

Latest Clinical Trials

Enrolling By Invitation PHASE1, PHASE2 NCT06851767

Base-Edited Hematopoietic Stem/Progenitor Cell X-Linked Severe Combined Immunodeficiency Gene Therapy

National Institute of Allergy and Infectious Diseases (NIAID)
INTERVENTIONAL
Updated Dec 15, 2025
Not Yet Recruiting NCT07133685

Evaluation of Serum IL-7 as a Biomarker in Breast Cancer

Assiut University
OBSERVATIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 2
pubmed Nov 25, 2020

Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.

Khavinson. V Kh VK; Linkova. N S NS; Kvetnoy. I M IM; Polyakova. V O VO; Drobint...

The study shows that the peptide thymalin can push early‑stage blood stem cells to become mature T‑cells that are important for fighting viruses like COVID‑19. It cuts down markers of immature cells and boosts a marker (CD28) linked to strong immune responses.

Utility 2
pubmed May 24, 2018

Effect of Thymalin on the Tumor and Thymus under Conditions of Activation Therapy In Vivo.

Zhukova. G V GV; Schikhlyarova. A I AI; Barteneva. T A TA; Shevchenko. A N AN; Z...

In a rat study, the peptide Thymalin given at doses lower than typical therapeutic levels slowed down or even shrank tumors in more than half of the animals. It also boosted activity in the thymus, a key immune organ, and seemed to help the animals stay calm and less stressed. The researchers think the good results come from using low doses and adjusting them over time.

Browse All Studies