Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study.
Loo. Wings T Y WT; Dou. Y D YD; Chou. W K J WK; Wang. Min M
Key Findings
- Thymosin‑alpha‑1 reduced interferon, TNF‑α and IL‑6 levels
- Treated teeth showed better periodontal healing and less ankylosis
- The treated teeth lasted longer than controls
Practical Outcomes
- These results are specific to dental trauma care and don’t translate into a usable protocol for general health, longevity, or performance goals. Biohackers looking for systemic benefits of thymosin‑alpha‑1 won’t find actionable guidance here.
Summary
The study shows that giving thymosin‑alpha‑1 after a knocked‑out tooth is re‑implanted lowers inflammation and helps the tooth heal better and stay alive longer, compared to just using saline.
Abstract
This study investigates the short-term and long-term effects of thymosin alpha 1 (Talpha1) on reimplantation of avulsed teeth. Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1. The teeth were reimplanted after treatment with Talpha1 or saline. Patients were monitored for both short-term and long-term parameters. The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05). The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth. The use of Talpha1 has both short-term and long-term beneficial effects during reimplantation of avulsed teeth.
Study Information
pubmed
2008
2008-06-01T00:00:00.000Z
10.1016/j.ajem.2007.09.007
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